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• Doravirina esquema recomendado en las nuevas guías EACS 2021 de tratamiento Antirretroviral del HIV.
Regímenes recomendados
Regimen | Main requirements | Additional Guidance (see footnotes) |
Recommended regimens | ||
2 NRTIs = INSTI | ||
ABC/3TC = DTG ABC/3TC/DTG | HLA-B*57:01 negative HBsAg negative | I (ABC: HLA-B*57:01, cardiovascular risk) II (Weight increase (DTG)) |
TAF/FTC/BIC | II (Weight increase (BIC, TAF)) | |
TAF/FTC OR TDF/XTC + DTG | II (Weight increase (DTG, TAF)) III (TDF: prodrug types. Renal and bone toxicity. TAF dosing) | |
TAF/FTC OR TDF/XTC = RAL qd or bid | II (Weight increase (RAL, TAF)) III (TDF: prodrug types. Renal and bone toxicity. TAF dosing) IV (RAL: dosing) |
1 NRTI = INSTI | ||
XTC + DTG or 3TC/DTG | HBsAg negative HIV-VL < 500,000 copies/mL Not recommended after PrEP failure | II (Weight increase (DTG)) V (3TC/DTG not after PrEP failure) |
2 NRTIs = INSTI | ||
TAF/FTC OR TDF/XTC + DOR or TDF/3TC/DOR | II (Weight increase (TAF)) III (TDF: prodrug types. Renal and bone toxicity. TAF dosing) IV (DOR: caveats, HIV-2) |
Alternative regimens | ||
2 NRTIs = INSTI | ||
ABC/3TC + RAL 400 mg bid | HBsAg negative HLA-B*57:01 negative | I (ABC: HLA-B*57:01, may delay starting ART) V (RAL in pregnancy, bid dosing) |
2 NRTIs = NNRTI | ||
ABC/3TC + EFV | HLA-B*57:01 negative HBsAg negative HIV-VL < 100,000 copies/mL At bedtime or 2 hours before dinner | I (ABC: HLA-B*57:01, may delay starting ART) VIII (EFV HIV-2 & group 0) |
TDF/XTC of TAF/FTC = EFV or TDF/FTC/EFV | At bedtime or 2 hours before dinner TAF/FTC not recommended in first 14 weeks of pregnancy | III (Tenofovir salts) IV (TAF & pregnancy) VIII (EFV HIV-2 & group 0) |
TDF/XTC of TAF/FTC = RPV or TDF/FTC/RPV or TAF/FTC/RPV | CD4 count > 200 cells/μL HIV-VL < 100,000 copies/mL Not on gastric pH increasing agents With food TAF/FTC not recommended in first 14 weeks of pregnancy | II (Tenofovir salts) IV (TAF & pregnancy) IX (RPV exposure during 2nd and 3rd trimester, HIV-2) X (Interactions) |
2 NRTIs = PI/r | ||
ABC/3TC + DRV/r 600 mg/100 mg bid | HLA-B*57:01 negative HBsAg negative With food | I (ABC: HLA-B*57:01, may delay starting ART) VI (DRV dosing) VII (COBI boosting) |
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• El objetivo de la modificación del tratamiento debe ser eliminar o mejorar los eventos adversos, facilitar el tratamiento adecuado de las comorbilidades y mejorar la calidad de vida, el tratamiento con INSTI o TAF podría estar asociado a incremento de peso.
• Si el regimen antirretroviral no incluye un booster, TAF o TDF tienen un riesgo similar de eventos renales que llevan a la discontinuación a corto plazo y de fracturas ósea.
![](https://conecta.msd.com.ar/wp-content/uploads/sites/11/2021/12/barra-delstrigo-03.png?w=1024)
Lo invitamos a conocer las guías EACS.
![](https://conecta.msd.com.ar/wp-content/uploads/sites/11/2021/12/delstrigo-01-02-02.png?w=1024)